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ImmunoRNAses

Antibody-targeted delivery of ribonucleases as effector moieties for selective killing of tumor cells

A further core competence of VANUDIS is the generation of antibody-based therapeutics with extended effector functions. 

In particular, the founders of VANUDIS have a long-standing expertise in the preclinical development of such compounds by employing radionuclides and amphibian and human ribonucleases as cytotoxic effector components. 

The key-advantage of using ribonucleases as effector moieties for antibody-based immunotherapeutics is their significantly lower immunogenic and toxic potential when compared with classical antibody drug conjugates (ADCs).